1. Practice Spares - I can't emphasize enough how important spares are. Making spares is one of the most important bowling tips that there is. You can have a great game and throw lots of strikes, but every spare you miss costs you 10+ pins. You could be on your way to a great 250 game, then miss 2-3 spares, and all of a sudden you're only at 210.
2. Don't get down about the bad shots. - Every once in a while, even the best bowlers, will make bad shots from time to time. Don't get down on yourself, just bowl one frame at a time, and think about what you need to do next to fix the mistake. Everyone has bad days too. If you have a bad day bowling, sometimes you just need to take a couple days off, then get back to it.
3. Practice! - Practice is the most important part of any sport. You will see a direct correlation between amount of time practicing and your scores.
4. Buy a new ball. - A new ball can definitely improve your game. A new bowling ball will typically hook more and carry more strikes.